Source: http://ojoconelsordo.com/?p=2097
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Source: http://ojoconelsordo.com/?p=2097
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Apr. 11, 2013 ? Clinical pharmacologists at Heidelberg University Hospital have achieved major progress for improving the reliability of drugs. In a pharmacological study, they showed for the first time that interactions between drugs can be detected with minute doses in the range of nanograms. However, at these low doses, the drugs are neither effective nor do they have side effects. This means that studies on interactions occurring in drug combinations can be conducted practically without posing risks or negative impacts on the participants. This is true not only for healthy volunteers, as has been observed to date, but also for patients. The study was published in the medical journal Clinical Pharmacology & Therapeutics.
"Many chronically ill or elderly patients today take several different drugs. Around two percent of all hospital stays in Germany are the result of interactions between the drugs," said Professor Walter E. Haefeli, Medical Director of the Department for Clinical Pharmacology and Pharmacoepidemiology at Heidelberg University, where the new technique of "nano-dosing" has been developed and tested. "Many interactions could be avoided if we were aware of them and took them into account."
Drug combinations rarely studied for interactions
However, very few drug combinations have been systematically tested for interactions to date. "Many risks remain unknown to date and need to be studied," Prof. Haefeli explained. After initial tests conducted in animals, combinations are currentlybeing studied in healthy participants -- with the usual therapeutic doses. Depending on the drug, this can strongly impact the body. Furthermore, a healthy person may react differently to a drug than a sick person does. This means that study findings can only be transferred to a limited extent.
Using mass spectrometry, an ultrasensitive technique, the team led by Prof. Haefeli succeeded in drastically reducing the dose for studies on interactions in study participants. Mass spectrometers are so sensitive that they are able to identify the drug in a single drop of blood. The scientists conducted a study on interactions in 12 healthy test persons taking the fungicide ketoconazole and the sedative midazolam simultaneously. For the study, they administered midazolamdoses of 0.0000001 g, which was 30,000 times lower than the amount used for therapy. Comparisons with higher doses revealed that the drugs behaved identically at all concentrations. Therefore, even a minimal concentration in the body is sufficient to reliably predict the extent of the interaction during normal use.
Inhibition of the liver enzyme measurable in the nanogram range
With the help of ultrasensitive mass spectrometers, the speed with which a drug is degraded can be measured. They are used wherever small amounts need to be detected in liquids, e.g., contamination in drinking water, doping agents or environmental toxins. To this end, a small amount of blood or other body fluid is withdrawn after certain time intervals in order to determine the remaining concentration of the drug. The mass spectrometer sorts the molecules and determines their concentration. Based on their characteristic properties, the drugs can be reliably identified. "For the first time, we have proven that with this technique, we are able to find drugs in the blood even at extremely low doses, and that we can quantitatively determine them and identify their interactions," Prof. Haefeli said.
In the published study, the team investigated the interaction between the sedative midazolam, which is metabolized in the liver by the protein cytochrome P450 3A, and the fungicide ketoconazole, a well-known inhibitor of this cytochrome. The inhibition of the cytochrome and, in turn, the reduced degradation of midazolam, were already precisely measured in the nanogram dose. This interaction in particular plays an important role for patients who need to take several drugs simultaneously. Many drugs inhibit this enzyme, which metabolises around half of all regularly used medicines. However, if a drug is degraded too slowly, at normal doses, it accumulates in the body and, in the worst case, can cause toxicity.
Further studies planned
Prof. Haefeli and his team are now testing the new method in patients. "Since we can use minimal drug doses, these studies are also safe for patients," Prof. Haefeli explained. Heidelberg University pharmacologists will also examine the interactions of other medications that influence other metabolic enzymes. "The method could also be used in the many studies in which interactions are relevant for approval by the authorities, for instance," said Prof. Haefeli, looking toward the future.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/CT3s3p3DcIE/130411124010.htm
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There has been report after report that Microsoft Office is seriously, for real this time, coming to iOS, but now it appears that Office might not be making its way to iOS until late 2014. Yes, really. In an apparent leak of their Office product roadmap, called Gemini, Microsoft details different waves in which products will be launched, and Office for iOS and Android is scheduled for October 2014. ZDNet has the details:
Gemini Wave 1.0 (October 2013): Windows Blue app updates
Gemini Wave 1.5 (April 2014): Office for Mac; Office RT refresh; Perceptive Pixel support; Windows Phone support refresh
Gemini Wave 2.0 (October 2014): Outlook RT; Office for iOS/Android
If leak proves to be accurate, it shows that Microsoft has really lost the plot. Sure, plenty of people rely on Office for work, but people who want Office on their mobile devices have done one of two things: they?ve either already purchased a Windows Phone device and/or a Windows tablet, or they?ve found another solution on iOS or Android. Both Apple?s iWork and Google Docs are cheaper and while they might not have every feature of Office, they have the features that most people need. You also don?t need to buy them again when you want the latest version.
Many businesses might still be entrenched in the thought of needing Office, but that is changing, albeit slowly. But that change will continue and it will continue to build momentum. If Microsoft is really going to wait until fall of next year to launch Office for iOS, they?re going to find that many, maybe most, of their potential customers are going to have moved on, and I?m afraid that may surprise them. And it shouldn?t.
If this roadmap is real, by late 2014, do you think you'll still want or need Office for iOS?
Source: ZDNet
Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/7ME558q9a_Q/story01.htm
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"When we grow something in the soil and harvest it, we're always taking nutrients out," he says. The changes may be imperceptible initially, but eventually you'll find your plants are smaller, more susceptible to problems, and maybe discolored and misshapen. If your garden goes downhill and other problems like pests aren't too blame, you could have poor soil quality. Keep your soil healthy and fertile with this seven-step soil-improvement plan.
Or, try this quick test: Rub some soil in your hands, and if it's sandy, you'll feel the sand particles. If it's heavy clay, it will feel very slippery when wet because clay particles are the smallest. Heavy clay soil also is slower to drain and takes longer to warm up and dry off in the spring. Silty soil is usually found on land near water that may have flooded and left the silt sediment.
The preferred soil, says Heilig, is a sandy (but not too sandy) loam???it's easier to work with and drains quickly.
This is why a soil test is important???so you can choose the fertilizer with the correct ratio of nutrients. "What you need to do is put it down in the amounts you need and not apply stuff that you don't need," Heilig says. For instance, nitrogen often has to be added. Find a fertilizer with the correct phosphorus and potassium ratio and add nitrogen separately.
Conventional fertilizers are cheaper and easier to apply, but you won't get the same soil-building benefits. You can mix organic and conventional. One example: If you need to up potassium levels, use potassium sulfate or potassium, then revert to organic.
"You need to look at things in a holistic way," Heilig says. "There are about 16 nutrients that plants need, and the majority of fertilizers only give you about three or four." The best way to get the remainder is by composting. A simple method: Dig a hole in your garden about 16 inches deep and throw in your kitchen scraps. Cover it, and let the earthworms do their thing. You can do this in several areas of your garden where the soil needs help, both before you plant in the spring and after garden season.
With granular fertilizer, you'll need only about two applications, but you won't get the extra nutrients. Before you plant, put down all of phosphorus, potassium, and two-thirds of the nitrogen, and till into the soil. Put the remaining one-third of the nitrogen six to eight weeks after the garden is growing.
If you have poor-quality topsoil, heavy clay content, and a lot of rocks, some root crops, such as carrots, will be tricky. You can select varieties with shorter roots, and some of the many varietals that grow well in poor soil, such as these carrots and cabbage.
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LONDON (AP) ? While some Britons mourned the passing of Margaret Thatcher, others raised glasses of champagne in impromptu street parties. And "The Wizard of Oz" song "Ding Dong! The Witch is Dead" is surging up the UK singles charts.
A Guardian newspaper cartoon depicted Thatcher descending into hell, the Socialist Worker front page said "Rejoice," and a movie marquee was rearranged to read: "Margaret Thatchers Dead LOL."
Many societies soften their take on divisive leaders as they age ? notably the United States, where even unpopular presidents are warmly eulogized in death ? but emotions in Britain are as raw as they were when the Iron Lady was in power.
Yes, Thatcher was an unusually divisive figure blamed by many for crippling Britain's labor unions and sabotaging workers' rights, but the willingness of small groups of Britons to publicly mock a longtime national leader hours after her death reflects a British contempt for power and its practitioners that many believe stands in contrast to attitudes in the United States.
There were no similar scenes of jubilation after the 1994 death of Richard Nixon, a polarizing figure who is the only U.S. president to resign from office, said Robert McGeehan, an associate fellow at the Institute for the Study of Americas.
"This really shows the dissimilarity between the two countries," said McGeehan, a dual national who worked with Thatcher in academia after she left office. "One does not recall, with the passing of controversial figures in the U.S., anything remotely resembling the really crude approach we've seen over here," he said. "There is a class ingredient here that we simply don't have in America. They like to perpetuate this; the bitterness goes from father to son."
In contrast, he said, Nixon ? disgraced by the Watergate scandal and facing impeachment ? eventually rehabilitated his public image and was treated as a respected elder statesman by the time of his death.
There are key differences between the two political systems, despite their common roots. In Britain, the prime minister is not the head of state ? a position filled by the monarch, Queen Elizabeth II, who is also the head of the Church of England ? while in the U.S. the president fills the dual role as head of state and commander-in-chief of the armed forces.
While some Britons are comfortable condemning a prime minister they detested, they would not act that way after the death of the queen or a senior royal, said Robert Worcester, an American who founded MORI, one of Britain's leading polling firms.
"Any member of the royal family will be revered, but few prime ministers are," he said, pointing out that thousands of people stood on line for hours in the middle of the night for a chance to pay their respects to Queen Elizabeth, the Queen Mother, when she died in 2002 at age 101.
Worcester said there is general affection for Thatcher in many quarters but that it would not be possible, for example, to name a major naval vessel after her because shipbuilders would "put down their tools" rather than honor the woman blamed by many for destroying the labor movement. He predicted that some opponents would carry "Good Riddance" signs to her funeral next week.
The anti-Thatcher movement spread to Northern Ireland, with celebrations of her death in several cities and taunting graffiti appearing overnight. "Rot in hell Maggie Thatcher" was one offering in Belfast.
Americans tend to put presidents on a pedestal, particularly after they leave office and move beyond the political give-and-take of the Oval Office. They are called "Mr. President" for the rest of their lives ? and the first woman president will be called Madame President or something similar after she leaves office. But no one in Britain calls Tony Blair, John Major or Gordon Brown "Mr. Prime Minister."
There is also a strong tendency in Britain to tear people down after building them up, and many have no qualms about attacking leaders they disliked, even in the emotionally charged days between their death and their burial.
"Having lived in both places, I can see the UK is far more deprecating, far more critical, and has far fewer taboos in criticizing leaders," said Robin Niblett, director of the Chatham House think tank. "In a way, her death is allowing people to vocalize the sense of frustration they are feeling with the current economic crisis."
While others condemned anti-Thatcher rallies as in horrendous taste, Niblett said they reflect how Britain does not need to build any patriotic myths about its leaders.
"America is building itself still and needing to believe there is a higher goal to which all Americans aspire, despite the partisan battles," he said. "When I see the trashing of Thatcher, I think of how strong Britain is and how in a way we don't need to do that. We don't rally round the flag, except in the most desperate moments. We don't eulogize our politicians."
Source: http://news.yahoo.com/even-death-thatcher-draws-scorn-163952814.html
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Spectators take photos of Rory McIlroy, of Northern Ireland, as he chips on the seventh green during a practice round for the Masters golf tournament Tuesday, April 9, 2013, in Augusta, Ga. (AP Photo/Charlie Riedel)
Spectators take photos of Rory McIlroy, of Northern Ireland, as he chips on the seventh green during a practice round for the Masters golf tournament Tuesday, April 9, 2013, in Augusta, Ga. (AP Photo/Charlie Riedel)
Rory McIlroy, of Northern Ireland, hits on the seventh fairway during a practice round for the Masters golf tournament Tuesday, April 9, 2013, in Augusta, Ga. (AP Photo/Charlie Riedel)
Rory McIlroy, of Northern Ireland, catches a ball while hitting on the driving range during a practice round for the Masters golf tournament Tuesday, April 9, 2013, in Augusta, Ga. (AP Photo/Matt Slocum)
Rory McIlroy, of Northern Ireland, hits balls on the driving range during a practice round for the Masters golf tournament Tuesday, April 9, 2013, in Augusta, Ga. (AP Photo/Matt Slocum)
AUGUSTA, Ga. (AP) ? Three months into the season, Rory McIlroy feels as if it's already been a long year.
The splashy announcement of his Nike deal, and the commercial with Tiger Woods that raised hopes of a big rivalry. The missed cut in Abu Dhabi. The first-round exit from the Match Play Championship. Quitting halfway through the second round of the Honda Classic. The loss of his No. 1 ranking.
And now, McIlroy is ready to get started.
"I've always said the main golf season is from the start of April to the end of August, so that's when I want to play my best golf," McIlroy said Tuesday.
It all starts with the Masters.
McIlroy can't simply dismiss the last three months and the endless questions about the state of his game and his new equipment. He at least brings some measure of form to the first major championship of the year. Desperate to find his game, he added the Texas Open at the last minute and in turned out "almost perfectly." The 23-year-old from Northern Ireland didn't think about his swing, only his score. He challenged in the final round and wound up the runner-up.
Whether he's ready for Augusta National won't be known until Thursday. But at least he knows it's there.
"I've went through these patches before where I haven't played so well and the game feels quite far away, and then something clicks and then all of a sudden, it's back again," McIlroy said. "I probably should have learned more from it from last summer when I was going through those struggles. ... When I don't play my best, it's when I get into bad habits in my golf swing. Whenever my golf swing is where I want it to be, that's when I produce results.
"And that's what I've seen has started to happen over the past few weeks."
The problem has been the swing, not the clubs he was swinging.
Even so, McIlroy conceded the adjustment took some time. Woods took nearly five years before working all the Nike clubs into his bag. McIlroy did it all at once, and when he played poorly the first two months of the year, it only added to the scrutiny.
"The way I was hitting the ball at the start of the year, I needed a short game just to get myself around the golf course," McIlroy said. "Off the tee has been a big improvement. There was a little bit of an adjustment period getting the driver that really suited me. And once I got that, you gain confidence whenever you play rounds and you see yourself hitting good drives, hitting it in the fairway and setting yourself up with iron shots into the greens."
McIlroy has plenty at stake this year.
He already has two legs of the career Grand Slam, having set the scoring record at the U.S. Open when he won at Congressional in 2011, and then lapping the field at Kiawah Island last summer to win the PGA Championship. A win this year would put him exclusive company. Dating to 1960, Arnold Palmer, Jack Nicklaus, Tom Watson, Tiger Woods and Phil Mickelson are the only players to win majors in three straight seasons.
Boy Wonder would love for that to happen at the Masters, and he's provided enough evidence that it could happen. McIlroy smiled when he was introduced for his news conference, and the moderator mentioned his best finish was a tie for 15th. That was in 2011, the year he took a four-shot lead into the final round, and still was leading by one shot going to the back nine until his game imploded. He closed with an 80.
A year ago, he was one off the lead going into the weekend, and this time self-destructed on the front nine. He closed with 77-76 and tied for 40th.
But there is no denying the affection McIlroy has for the Masters, which he calls his favorite major. He remembers playing Augusta for the first, so inspired by the purity of the place that he was afraid to take a divot.
Just a month ago, he was happy to make the cut and make progress. Now his goals are back where they should be.
"Would anything less than a win be a disappointment this week? Yeah, it would be," he said. "Every time you come here to Augusta, you're wanting to win that green jacket, and every time that you don't, it's another chance missed. But if I'm sitting here on Sunday night and I've finished second or if I've give it a good run, you can't be too disappointed because you've had a great tournament. But the ultimate goal is getting one of those jackets."
Among those who could be in his way is Woods, the prohibitive favorite with wins at Torrey Pines, Doral and Bay Hill in the last few months.
There was hope of a rivalry between generations, only that hasn't materialized. They only thing they have in common this year is that both have a swoosh on their shirts, both started the year by missing the cut and both have celebrity girlfriends ? tennis star Caroline Wozniacki for McIlroy, Olympic ski champion Lindsey Vonn for Woods.
Woods has had plenty of rivals over the years, and sees McIlroy as the next one.
"Over the course of my career, I've had a few. Certainly, Rory is this generation," Woods said. "I've had Phil (Mickelson) and Vijay (Singh) and Ernie (Els) and David (Duval) for a number of years, and now Rory's the leader of this new, younger generation. So, yes, definitely."
McIlroy isn't so sure.
Never mind that he became the first player to win consecutive PGA Tour events with Woods in the field, or that he built a big gap in the world ranking by the end of last year. Padraig Harrington once said it could be McIlroy ? not Woods ? who has the best chance of breaking Jack Nicklaus' record of 18 professional majors.
Not so fast, McIlroy replied.
"When you speak of rivals, you tend to put rivals who have had similar success," McIlroy said. "He's got 77 PGA Tour wins. I've got six. He's got 14 majors. I've got two. If I saw myself a rival to Tiger, I wouldn't really be doing him much justice."
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An Elmo character poses for photos in New York's Times Square, Tuesday, April 9, 2013. A string of arrests in the last few months has brought unwelcome attention to the growing number of people, mostly poor immigrants, who make a living by donning character outfits, roaming Times Square and charging tourists a few dollars to pose with them in photos. (AP Photo/Richard Drew)
An Elmo character poses for photos in New York's Times Square, Tuesday, April 9, 2013. A string of arrests in the last few months has brought unwelcome attention to the growing number of people, mostly poor immigrants, who make a living by donning character outfits, roaming Times Square and charging tourists a few dollars to pose with them in photos. (AP Photo/Richard Drew)
A Super Mario character, left, uses a woman's mobile phone camera to photographer her with a pair of Elmo characters in New York's Times Square, Tuesday, April 9, 2013. A string of arrests in the last few months has brought unwelcome attention to the growing number of people, mostly poor immigrants, who make a living by donning character outfits, roaming Times Square and charging tourists a few dollars to pose with them in photos. (AP Photo/Richard Drew)
Elmo and two Hello Kitty characters pose for photos with a little girl in New York's Times Square, Tuesday, April 9, 2013. A string of arrests in the last few months has brought unwelcome attention to the growing number of people, mostly poor immigrants, who make a living by donning character outfits, roaming Times Square and charging tourists a few dollars to pose with them in photos. (AP Photo/Richard Drew)
A woman gives a monetary tip to characters in New York's Times Square after she photographed the girl with them, Tuesday, April 9, 2013. A string of arrests in the last few months has brought unwelcome attention to the growing number of people, mostly poor immigrants, who make a living by donning character outfits, roaming Times Square and charging tourists a few dollars to pose with them in photos. (AP Photo/Richard Drew)
NEW YORK (AP) ? Cookie Monster stands accused of shoving a 2-year-old. Super Mario was charged with groping a woman. And Elmo was booked for berating tourists with anti-Semitic slurs.
Times Square is crawling with entrepreneurs who dress up as pop-culture characters and try to make a few bucks posing for photos with visitors to the big city. But some of these characters are unlike anything you've seen on "Sesame Street" or at Disney World.
They smoke, they use foul language, and they can be aggressive. At least three of them have been arrested in the past seven months.
"He was using words that were really bad," said Parmita Kurada of Stamford, Conn., who told police she got into a dispute this week with a man in a Cookie Monster costume who demanded $2 for posing with her 2-year-old son, Samay.
Kurada said that when she told the Cookie Monster that her husband needed to get cash, the shaggy blue creature pushed the boy and began calling her and the child obscene names.
"It was very scary for us, and I was crying. I didn't want to provoke him, so I said, 'We'll give you the money, but stop yelling!'" she said.
Osvaldo Quiroz-Lopez, 33, was charged with assault, child endangerment and aggressive begging. His lawyer did not immediately return a call for comment.
Asked by a WNBC-TV reporter why he no longer likes the character he sees on "Sesame Street," little Samay said: "Because Cookie Monster give me boo-boo."
In the wake of the latest arrest, the bustling "Crossroads of the World" was filled Tuesday with performers, including multiple versions of Mickey and Minnie Mouse, Hello Kitty, a Transformer robot, Lady Liberty, Super Mario and Elmo.
Many of them are immigrants trying to eke out a living in what appear to be knockoff costumes.
As street performers protected by the First Amendment, they are free to roam Times Square and work for tips that average between $2 and $5 a photo as long as they don't block traffic, sell merchandise or demand payment, police say. That's a ticketable offense that can cost about $60.
"I don't think they should charge, but if they're unemployed or homeless, and this is the only way they can make money, it's OK," said Lauren Larcara of Oakland, N.J., who posed with a torch-carrying Statue of Liberty.
Laura Vanegas, a 45-year-old native of Ecuador, changes into her Liberty robes and applies copper-green face paint behind the Times Square military recruiting station. She said she picks up $30 to $50 on her eight-hour shift.
Steve Crass, dressed as a robot in fluorescent red and white plastic panels, said he has made as much as $280 during his six-hour stint in front of Toys R Us. He acknowledged: "Some of the characters are a little too aggressive."
Police spokesman Paul Browne said in an email that the department has had "occasional issues with the 'faux paws' in Times Square, but they're nominal."
The case against the Super Mario charged with groping is still pending. The Elmo accused of an anti-Semitic rant pleaded guilty in September to disorderly conduct and was sentenced to two days of community service.
City Council Speaker Christine Quinn called the Cookie Monster case "just horrible" and said lawmakers have been looking into how to regulate the characters. But she noted the issue is, well, fuzzy.
"It's very challenging legally because dressing up in a costume and walking around Times Square is, we believe, a First Amendment-protected activity," said Quinn, a candidate to be New York's next mayor.
Similar cases of misbehavior by costumed performers have been reported in Hollywood.
Disney did not respond to a request for comment, while the Sesame Workshop, the organization behind "Sesame Street," said it has not authorized such uses of any its characters in any city and is looking into what actions it can take.
Anthony Elia, a New York lawyer in the intellectual-property field, said the entertainment groups probably have a case for trademark infringement, but "the challenge probably would be getting a bunch of self-employed entrepreneurial individuals to stop."
It's not the easiest way to make a living. On a day when temperatures pushed 80, they sweated in their outfits, coming out from under their oversized costume heads only to grab a hot dog or a smoke. When one posed for a photo, two or three others dashed over and joined in.
"Want to take a picture?" a furry red Elmo asked a tourist. Moments later, he declined to speak to a reporter, saying through his costume, "I no speak English."
A Minnie Mouse offered a toddler in a stroller her hand and positioned herself at the handlebar. A Super Mario rushed over to join her.
"She said, 'Can you give us money?'" said the child's mother, Melanie Somogyi of Hamilton, Ontario. "And they grabbed the stroller!"
___
AP reporters Colleen Long, Karen Matthews and Jennifer Peltz in New York contributed to this report.
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Many security vendors offer a three-tier product line: standalone antivirus, security suite, and mega-suite. Bonus features in a mega-suite can include backup, tune-up, password management, encryption, and more. ZoneAlarm Extreme Security 2013 ($89.95 direct for three licenses) occupies the mega-suite slot in Check Point's product line, but it's woefully lacking compared to the competition and even compared to its own 2012 edition.
This product's main window is identical to that of the base-level ZoneAlarm suite. The only visible difference is that the Tune-up link is no longer disabled.
Limited Features
The product comparison chart on the ZoneAlarm website indicates that ZoneAlarm Extreme offers PC Tune-up and keylogger protection, features not found in ZoneAlarm Internet Security 2013. However, keylogger protection isn't entirely ready. My Check Point contact explained that the company is "transitioning to a new homegrown keylogger technology that has less conflicts with third party software," and that at present keylogger protection is handles by the behavioral detection component.
Last year's version included a license for ZoneAlarm DataLock, a whole-disk encryption product, but that product is "being phased out." A new File and Folder lock product replaces it. However, that product it's not yet integrated into ZoneAlarm Extreme.
"ForceField" virtualization technology was a big part of the first ZoneAlarm Extreme. This technology worked to protect the browser from drive-by downloads and prevent any Web-based malware from making damaging changes to the system. A glowing browser window border served as a reminder of its protection. And... ForceField is out. "It was a support and development nightmare," my Check Point contact said. "A more compatible replacement technology [is] in the works, but [we] are still in the awkward transition phase."
Limited Tune-Up
The Tune-Up feature isn't installed along with the rest of ZoneAlarm Extreme, but the first time you try to run it, you're directed to a Web page that lets you download and activate it. I smelled a rat at this very first step. Yes, it offered a button to let me install now, but another button proposed that I "Update Now" for $9.95. The extra $10 you pay for ZoneAlarm Extreme gets nothing but this feature; now they want another $10?
It turns out ZoneAlarm's PC Tune-Up is a stripped-down and re-branded version of a tool from Large Software. This version focuses specifically on the Registry, omitting features like management of startup programs, scheduling, and getting rid of useless files.
When you launch the Tune-Up component it goes through four stages of Registry cleanup. It backs up the Registry, scans for problems, fixes found problems, and finally defragments the Registry. Expert users can pick and choose which problems to fix; most users will just fix everything. On the off-chance that a "fix" breaks something, you can revert to the backup created in the first step.
I ran a Tune-Up on my physical test system, running Windows 7. I hit a snag at the very first step, as the utility reported numerous errors backing up the Registry. After I clicked the error messages away, though, it reported that the backup completed successfully. It found and fixed hundreds of Registry problems and proceeded to defragment the Registry, after which I had to reboot.
Once I rebooted, I ran the Tune-Up again... and discovered that it had done nothing the first time around. It still displayed error messages during backup, still found and allegedly fixed the same problems, and still found the Registry in need of defragmentation. After a third run-through, for a sanity check, I contacted tech support.
They suggested I launch the Tune-Up application by right-clicking and choosing "Run as Administrator." That didn't make a lot of sense, given that I was using an Administrator account, but I gave it a try. This time it worked. I wonder how many ordinary users will run Tune-Up over and over, not realizing that it isn't doing anything?
Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/dVeK9nKrNFk/0,2817,2417459,00.asp
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'I think it's probably one of the most interesting dynamics on the show,' Sophie Turner tells MTV News.
By Amy Wilkinson
Source: http://www.mtv.com/news/articles/1705121/game-of-thrones-sansa-margaery-friendship.jhtml
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WASHINGTON (AP) ? An immigration bill being developed in the Senate is completely consistent with President Barack Obama's approach ? even though the Senate plan would tie border security to a path to citizenship in a manner Obama administration officials have criticized, Senior White House adviser Dan Pfeiffer said Sunday.
Pfeiffer didn't answer directly when asked on "Fox News Sunday" whether Obama would sign legislation making a path to citizenship for the estimated 11 million people living here illegally contingent on first securing the border, as negotiators in the Senate are doing. But he suggested Obama was supportive of the Senate plan.
"What they are looking at and what has been talked about in the Gang of Eight proposal is 100 percent consistent with what the president is doing so we feel very good about it," Pfeiffer said. "And they are looking at it in the right way."
Obama has stressed that a path to citizenship should not have major hurdles in front of it, and some immigration advocates believe that's what a requirement for a secure border would amount to. Obama's Homeland Security Secretary, Janet Napolitano, has rejected the argument that border security must be achieved before a comprehensive immigration package or any pathway to legalized status can be done.
But Republicans involved in the Senate negotiations have made clear that border security is a must for them before those living here illegally can be allowed to move toward citizenship.
"We are going to secure that border and it will be tied to a pathway to citizenship or there will be no deal," Sen. Lindsey Graham, R-S.C., a member of the so-called Gang of Eight negotiating an immigration deal, said Sunday on NBC's "Meet the Press."
Graham also said that disagreement over a new low-skilled worker program is still hanging up an immigration deal ? even after an agreement a week ago between the AFL-CIO and the U.S. Chamber of Commerce.
Graham said negotiators are revisiting the low-skilled worker deal. He didn't offer details, but his comments suggested senators might be encountering last-minute difficulties finalizing their bill, which they had hoped to roll out as early as this week.
"We've got an agreement between labor and business about the guest worker program, but we're revisiting that," Graham said.
"If we're reasonable with the 11 million, if we'll give them a path to citizenship that's earned and hard and fair ? get in the back of the line, pay taxes, learn the English language ? then the Democratic Party has to give us a guest-worker program to help our economy," Graham said. "That's what we're arguing over."
The hard-won deal between the AFL-CIO and Chamber of Commerce would ultimately allow up to 200,000 workers a year into the U.S. to fill jobs in construction, hospitality, nursing homes and other areas where employers now say they have a difficult time hiring Americans or bringing in foreign workers legally. Even after the deal was struck, some industries, such as construction, continued to voice complaints about the terms, but other lawmakers and officials with the groups involved have continued to voice support and insisted it will hold.
Graham sounded optimistic overall saying senators hope to complete their deal in the next couple weeks. He predicted it will pass the 100-member Senate with 70 votes in favor.
Meanwhile two House lawmakers involved in writing a bipartisan bill in the House sounded notes of optimism that they, too, would have a deal soon that could be reconciled with the Senate agreement.
"I am very, very optimistic that the House of Representatives is going to have a plan that is going to be able to go to a conference with the Senate in which we're going to be able to resolve this," Rep. Luis Gutierrez, D-Ill, said Sunday on CNN's "State of the Union".
Source: http://news.yahoo.com/pfeiffer-embraces-senate-immigration-plan-144806910--finance.html
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We know you've got questions, and if you're brave enough to ask the world for answers, then here's the outlet to do so. This week's Ask Engadget inquiry is from Chris, who wants to find a low-cost way of getting his wife online. If you're looking to ask one of your own, drop us a line at ask [at] engadget [dawt] com.
"My family's already invested in Android, and my as wife isn't the most computer literate, I thought an Android PC stick would get her online without any fuss. However, there are so many available, I thought I'd ask which one's worth my time, if any? Thanks!"
Well, when it comes to Android sticks, you're spoilt for choice. After all, you've got enterprise-level offerings like Project Ophelia through to the FAVI Streaming Stick, the GameStick, Always Innovating and, of course, the humble MK802. When it comes to which one you should buy? Let's leave that up to the mood of the vox populi, who will be sharing their opinions below the break.
Filed under: Home Entertainment
Source: http://www.engadget.com/2013/04/06/ae-best-android-on-a-stick/
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Skin care regimens, however, have different effects on each skin type. This means that skin care treatments and products work well in certain types of skin. Hence, it is really very important for a person to determine his skin type in order to know which products are best on his skin.
Among the five skin types, sensitive skin is probably the hardest type to maintain and handle, for it is more prone to burning, stinging, drying, itching, and other skin complications. People with sensitive skin type also experience adverse reactions with sudden climate changes, certain skin care products, and abrupt feelings of stress.
According to statistics, fair-skinned individuals are usually the ones who have sensitive skin, regardless of ethnic background. In addition to the common complications associated with sensitive skin are a couple of serious skin conditions like eczema, rosacea, and psoriasis.
Sensitive skin care info
Although sensitive skin is the type that is more prone to skin complications, maintaining this skin type is not really that hard once a person learns how to simplify his or her daily skin care routines. It is not really advisable for one to maintain sensitive skin with so many products and treatments, for these will only result to serious irritations and blemishes. Over-washing sensitive skin is also a big no no. Since this type of skin easily reacts with environmental elements, sunscreen is a must in caring and maintaining the skin.
How to choose the best skin care product for sensitive skin
Today?s market offers numerous skin care options for consumers to choose from. The dilemma, however, is how to find the one that best suits a sensitive skin type. Below is a quick guide on how to choose skin care products for sensitive skin:
1. Look for organic or natural skin care products instead of the conventional ones as these are the best aids for sensitive skin. Organic or natural skin care products do not contain dye or perfume ingredients that are harmful to the skin.
2. As for cleansing a sensitive skin, it is best if one makes use of a soap-free cleanser product. People with sensitive skin are also encouraged to use skin care products that contain ingredients like salicylic acid if acne still occurs.
3. Always look for a mild and alcohol-free astringent products for these are also perfect skin care aid for sensitive skin. However, if irritation or redness occurs, immediately discontinue use.
4. When using or applying make up, purchase cosmetic products or items that are non-comedogenic and water-based. Although these cosmetics are a bit more expensive, these are safer and milder on the skin, thus, preventing irritation and dryness.
5. As for moisturizers, those with sensitive skin should go for the products that are fragrance-free and hypoallergenic. Regularly maintaining the skin with moisturizers also prevents aging signs such as wrinkles and facial lines.
Source: http://www.nmfbihop.com/important-facts-on-sensitive-skin-care
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Source: http://feeds.feedburner.com/lern2play
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A long plane ride is a pretty boring thing. Sure, you could get out your laptop and work, or keep handing over your plastic for those tiny bottles of entertainment, but Facebook has another idea -- with Facebook Home and the HTC First you can bring along all your friends. And cats.
While we imagine the average Facebook user's feed will be slightly different (and a lot less safe for work), this is a good ad that gets the idea across. I have a feeling we're going to see a lot more like it.
Source: YouTube
Source: http://feedproxy.google.com/~r/androidcentral/~3/EPpFamzEzj4/story01.htm
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(Reuters) - Canada's main stock index was set to open lower on Friday after Canadian and U.S. jobs data came in much weaker than expected, raising concerns about the health of the North American economy.
TOP STORIES
American employers hired at the slowest pace in nine months in March, a sign that Washington's austerity drive could be stealing momentum from the economy. The economy added just 88,000 jobs last month.
Canada posted the single worst monthly jobs loss in more than four years in March, another sign the economy is struggling to cope with weak foreign markets and a strong Canadian dollar.
Walt Disney Co expects to begin layoffs at its studio and consumer product divisions within the next two weeks, according to two people with knowledge of the matter, in the latest cost-reduction step to emerge from a company-wide review.
Samsung Electronics, the iPhone's main adversary, estimated its January-March operating profit rose 53 percent to 8.7 trillion won as sales of mid-tier smartphones helped the South Korean giant tide over the off-peak season.
Hewlett-Packard Chairman Ray Lane, who has come under fire from shareholders for his role in the acquisition of software company Autonomy Plc, has relinquished his post in the No.1 personal computer maker's latest board shake-up.
Boeing may carry out a certification test flight of its grounded 787 Dreamliner with a revamped battery system on Friday, a key step toward returning the state-of-the-art aircraft to flight, a U.S. government official said on Thursday.
(Reporting by Samarendra Sahoo; Editing by Jeffrey Hodgson)
Source: http://news.yahoo.com/tsx-set-open-lower-weak-jobs-data-130646660--sector.html
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Two gay seniors at George Washington University say they feel alienated because the chaplain at George Washington?s Newman Center rejects homosexuality, and they aren?t going to take it anymore.
The seniors, Damian Legacy and Blake Bergen, have announced a coordinated campaign to rid the campus of the Roman Catholic priest, reports The GW Hatchet, the school?s independent student newspaper.
They also assert that 12 or more students have quit the Newman Center in recent years because they can?t tolerate Father Greg Shaffer?s ardent anti-gay ?? and, for the record, anti-abortion ? beliefs.
Shaffer has worked for five years at George Washington?s Newman Center. He told the Hatchet that religion and unrestricted speech ?play a vital role at a diverse university like GW.?
Legacy and Bergen say they are primarily upset about the counseling Shaffer offers. They say he urges students who have homosexual feelings to lead a life of celibacy.
Catholic Church doctrine maintains that homosexual desire isn?t a sin, but acting on that desire is, according to the website Catholic.com.
Legacy told the Hatchet that he spent considerable time at the Newman Center during his first two years at George Washington. He was an altar server at mass. He believed that he would become a Catholic priest after graduating.
All that changed, though, when Legacy told Shaffer that he and Bergen had entered a homosexual relationship. Shaffer allegedly charged Legacy with being immoral and lacking in faith.
?To have my faith leader view me that way, just because of one piece of the way that God made me, and to think that one part is responsible for the destruction of my human dignity, it just didn?t?I can?t even begin to describe the mental conflict that it creates,? Legacy told the Hatchet.
The two gay seniors are also unhappy about a blog post Shaffer authored back in May 2012, just after President Barack Obama publicly endorsed gay marriage.
?As Vatican II states, God is the author of marriage. He has defined marriage as between a man and a woman,? Shaffer then wrote. ?Every single rational person knows that sexual relationships between persons of the same sex are unnatural and immoral. They know it in their hearts.?
The plan to oust Shaffer includes the creation of a video containing the statements of several students who have left GW?s Newman Center. That video, Legacy and Bergen hope, will surely arouse the generally left-leaning campus to anger, thus forcing school officials to act.
Other aspects of the proposed GW Newman Center insurgency include filing a formal complaint with the administration and conducting a series of prayer vigils outside the center.
Legacy and Bergen will also distribute a letter to high-ranking administrators. According to The Hatchet, the letter will cite academic studies connecting homophobic behavior to loss of appetite, insomnia and other detrimental psychological consequences.
Finally, Legacy will request that GW?s Student Association defund the Newman Center (which is affiliated with the school but officially part of the Roman Catholic Church). This year, the Center reportedly collected $10,000 in funding.
Last semester, Legacy presented a report to the school?s Office for Diversity and Inclusion explaining that other schools, such as New York University, vet and evaluate religious leaders before allowing them to work with campus-affiliated groups.
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Source: http://news.yahoo.com/students-try-banish-catholic-chaplain-campus-anti-gay-122022298.html
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Plenty of T-Mobile users recently had reason to rejoice when the carrier unveiled its long-awaited iPhone. But not everyone needs a phone as powerful as that. There's still a market for simple flip phones, and the $19.99 Samsung T159 is there for anyone who's looking for a phone to just make calls. It's simple to use, with a large number pad and good call quality. But the camera is poor, there are few other features, and the phone ultimately costs a little more than it probably should. It's a decent option if you want something simple, but you don't have to look too hard to find something better.
Design and Call Quality
The Samsung T159 measures 3.8 by 1.9 by 0.6 inches (HWD) and weighs just 2.9 ounces. It's made entirely of black plastic with a lightly textured finish on the back panel. There's a volume rocker on the left, and a Camera button on the right, below the covered power/nonstandard headphone jack. The black-and-white 1.07-inch external display shows the time, date, reception, and battery life at a glance, and will show the name or number for incoming calls, but it only stays illuminated for a few seconds before turning off.
The internal 1.8-inch display features 160-by-128-pixel resolution. It's very small, and there's no way to change the font size, but at least the default is readable. The number pad below is better. The keys are large and backlit, though there isn't much separation. Still, they're big enough that you probably won't press the wrong button. Above the number keys is a simple directional pad with a Select button in the middle.
The T159 is a quad-band (850/900/1800/1900 MHz) GSM device that runs on T-Mobile's HSPA 7.2 network (there's no Wi-Fi support). Reception is good and call quality is above average. Voices sound very full and clear in the phone's earpiece. Calls made with the phone are also quite good, with solid background noise cancellation. The speakerphone sounds clear but a bit thin, and is loud enough to hear in the car, but not outside. The T159 had no trouble pairing with my Jawbone Era?Bluetooth headset, and the Nuance-powered voice dialing app worked well. Battery life was a little short, at 5 hours and 33 minutes of talk time.
T-Mobile's new contract-free plans start at $50 per month, which gets you all the talk and texts you want, along with 500MB of high-speed (3G) data per month, after which your speeds are slowed to 2G. $60 gets you 2GB of high-speed data, while $70 gets you unlimited high-speed data. These are excellent rates compared to competitors like AT&T and Verizon. On the other hand, you're paying for all that data on a phone that just can't do much with it. If all you want is a simple phone to make calls, you can save $10 per month and still get unlimited talk and text with a phone on Virgin Mobile.
And while the T159 costs just $19.99 up front, you have to pay a $3 monthly fee for 24 months, which works out to a total $91.99. You can also pay for the whole thing up front and avoid the monthly surcharge. But really, a phone like this should be free.
Apps, Multimedia, and Conclusions
The UI is responsive and easy to navigate, though some functions can be hard to find. The home screen is mostly blank, aside from links to the main menu and Web browser. The main menu features nine different shortcuts, which link you to your contacts, messages, settings, and a T-Mobile app store.
There are no email or IM clients, though you can still access email through the Access NetFront 4.2 browser for WAP pages. But the phone's screen is so small, and the browser is so outdated, that trying to surf the Web feels like more trouble than it's worth. For text messages, you'll need to type out letters using the number keys, which is always a pain, but at least the number keys are big and easy to press. The T159 displays messages individually, or threaded, in the style of a conversation.
There's no microSD card slot, but you get about 100MB of free storage, which is more than enough, since there isn't much you can store. Multimedia support is virtually nonexistent, as there are no music or video players.
You do get a 1.3-megapixel camera, which you can access by pressing the Camera button on the right side of the phone. Images look dark and grainy, especially those taken indoors. Videos max out at a tiny, blurry 320 by 240 pixels, and you can only record 30 seconds at a time, not that you'd want more.
The Samsung T159 doesn't try to reinvent the wheel. But in a world filled with seemingly space-age smartphones, sometimes something old and familiar can be comforting, which is the case with the T159. But it's not hard to find better options. The keyboarded Samsung Gravity TXT?is a better choice if you like texting, and if you're interested in functions beyond just making calls, you're better off with a smartphone. Phones like the HTC One S?or HTC Windows Phone 8X?cost a lot more than the T159 overall, but you're still paying the same monthly service fees, and you're getting a phone that can do a whole lot more.
Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/IV7yFc4Loc0/0,2817,2417456,00.asp
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Google celebrates the 366th birthday of German artist and naturalist Maria Sibylla Merian, whose observations of insects and their habitats stood at the dawn of the scientific revolution.?
By Eoin O'Carroll,?Staff / April 2, 2013
The Google doodle today pays tribute to Maria Sibylla Merian, the German illustrator.
In many ways, the artist and naturalist Maria Sibylla Merian, celebrated by Google Tuesday on her 366th birthday, fell victim to her own artistic talent. Ms. Merian's drawings, engravings, and paintings were so good that most people ended up ignoring the extraordinary observations that accompanied them. ??
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A flair for the visual ran in her family. Born in Frankfurt am Main in 1647 to a patrician family of engravers, Merian began drawing and painting at an early age, eventually marrying the still-life painter Johann Andreas Graff. The two moved to Nuremberg, where Merian created embroidery designs and gave drawing lessons to young women from wealthy families. While in Nuremberg, she published three volumes of decorative drawings of flowers, designed for use by embroiderers, cabinetmakers, and other artisans.
But making pictures wasn't Merian's only passion. By the age of 13, she was already raising caterpillars, carefully noting their diets, their behaviors, and the timing of their metamorphoses.?
In her thirties, she published two books of engravings of moths, butterflies, and their caterpillars, with accompanying descriptions. Then, in her fifties, she?traveled?with her daughter to Dutch Suriname to study insects there, in 1705 publishing "Metamorphosis insectorum surinamensium," a collection of 60 engravings, each showing a tropical insect in its full life cycle along with the native plant on which it lived. The work is widely regarded as her masterpiece.
All along the way, Merian racked up a series of remarkable firsts. She was the first European naturalist ? male or female ? to undertake an independently financed expedition to the New World. She was arguably the first naturalist trained in the fine arts to study a specific type of organism for a sustained period, and one of the first to depict tropical species in their natural colors.?
As Gettysburg College biologist Kay Etheridge argues in a 2011 article, she may have been the world's first ecologist, that is, the first person to document the interactions between different species, emphasizing what we would today call the food chain. You could even make the case that she was the first female biologist of the modern era.?
Indeed, Merian was a member of one of the first generations?in the West to take seriously the concept of empirical observation. It was only during her lifetime that a consensus among scholars began forming around the concepts of experimentation, repeatability, and peer review. As Los Angeles Times art critic Holly Myers noted in a 2008 review of a Merian exhibition at the Getty Museum, her era was one of upheaval?"which saw science, religion and art locked in a state of muddled and sometimes violent agitation."
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Some wristwatch dealers in Lagos on Tuesday said the introduction of cell phones had caused a drop in the sale of wristwatches.
They told the News Agency of Nigeria (NAN) in separate interviews that their sales had dropped since the introduction of cell phones.
NAN reports that Global System of Mobile Communication (GSM) was introduced in 2001 by the administration of former President Olusegun Obasanjo.
Mr. John Emeka, Chairman, Avido Supermarket in Ketu, Lagos, told NAN that sale of wristwatches had dropped since phone handsets were also offering the facility.
?I have been operating my supermarket since 1994 and before the inception of cell phones, I sold close to 10 wristwatches a day.
?But since 2001, I hardly sell 15 wristwatches in a month,? he said.
Malam Audu Abubakar, another wristwatch seller in Lawanson, corroborated Emeka?s view.
?As a result of reduction in the sale of wristwatches, I have diverted into selling chains and rings,? Audu said.
According to him, the only type of wristwatch selling in the market now is gold plated wristwatches because most customers believed that their value appreciates with time.
Mr. Suleiman Kabir, a wristwatch hawker, said that some people believed wristwatches were fashion items and still preferred to buy them while others thought it was a waste of resources.
Mr. Kenny Agunbiade, a wristwatch repairer, told NAN that he had learnt to repair phones since few people were now using wristwatches.
Agunbiade said that he was making more money repairing phones than selling wristwatches.
He urged his colleagues to learn how to repair handsets as an alternative source of income.
Mrs. Lola Akinlade, a food seller in Iganmu, said that a wristwatch was now a fashion item to complement one?s dressing.
?I can no longer waste my money on a wristwatch since what I need is on my phone,? she said.
Mrs. Felicia Falade, a recharge card seller, said she rarely remembered using a wristwatch since the introduction of cell phones.
Falade said that the purpose of using a wristwatch was to know the time, a facility which a cell phone was also providing.
Posted by pmnews on April 3, 2013, 2:43 pm. Filed under Business, Business News, Telecomms. You can follow any responses to this entry through the RSS 2.0. You can skip to the end and leave a response. Pinging is currently not allowed.Source: http://pmnewsnigeria.com/2013/04/03/cell-phones-reduce-patronage-for-wristwatches/
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Today, Times Internet, the digital arm of Times of India, is announcing a strategic partnership with Business Insider, the online news publication founded by Henry Blodget, for the launch of Business Insider India. The move comes hot on the heels of a similar deal announced between Times Internet and Gawker Media in January 2013, part of its Times Local Partners initiative.Source: http://feedproxy.google.com/~r/Techcrunch/~3/Dhgdo04fRG8/
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